| Registro completo |
| Provedor de dados: |
BABT
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| País: |
Brazil
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| Título: |
Antiproliferative Effect of Urera baccifera Leaves Against Ovarian Carcinoma Cell Line (OVCAR-3)
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| Autores: |
Benvenutti,Régis Carlos
Gomes,Denise B.
Zanchet,Barbara
Locateli,Gelvani
Vechia,Cristian Alex Dalla
Zanotelli Serpa,Patrícia
Lutinski,Junir
Rodrigues Junior,Sinval Adalberto
Schönell,Amanda Patrícia
Diel,Kriptsan Abdon Poletto
Miorando,Daniela
Ernetti,Jackeline
Alves,Bianca de Oliveira
Zilli,Gabriela Adriany Lisboa
Banzato,Thais Petrochelli
Ruiz,Ana Lúcia Tasca Gois
Vidal Gutiérrez,Max
Vilegas,Wagner
Roman Junior,Walter Antônio
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| Data: |
2019-01-01
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| Ano: |
2019
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| Palavras-chave: |
Antitumor agents
Medicinal plants
Chemical analysis
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| Resumo: |
Abstract Natural products, especially phytochemicals, have been extensively studies and have exhibited important antiproliferative effects. The American native species Urera baccifera (L.) Gaudich. ex Wedd. (Urticaceae) is widely distributed in Brazil, where it is known as urtiga-vermelha or urtigão. The leaves are popularly used as anti-inflammatory, antirheumatic and in the treatment of gastric disorders. However, the antiproliferative potential of this plant against human tumor cells remain to be elucidated. In this study, we evaluated the antiproliferative effects of U. baccifera leaves extracts and fractions against a panel of human tumor cell lines in vitro besides a chemical evaluation of the most active sample by mass spectrometry (ESI-IT-MSn). The hydroalcoholic extract was inactive while dichloromethane extract showed moderate cytostatic activity against ovarian carcinoma cell line (OVCAR-3, GI50 = 1.5 μg/mL). More, the ethyl acetate and n-butanol fractions did not show important activity against tumour cell while the dichloromethane and hexane fractions showed moderate cytostatic activity against ovarian tumor cell line (OVCAR-3, GI50 = 12.7 and 9.4 μg/mL, respectively). Finally, the chemical profile evaluated by mass spectrometry (ESI-IT-MSn) allowed the detection of flavonoids in the HEU and hydroxylated fatty acid in DEU that can explain partially the biological effects observed. This is the first report of the antiproliferative effects of U. baccifera, and DEU has shown potential as a promising source of bioactive compounds.
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| Tipo: |
Info:eu-repo/semantics/article
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| Idioma: |
Inglês
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| Identificador: |
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132019000100412
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| Editor: |
Instituto de Tecnologia do Paraná - Tecpar
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| Relação: |
10.1590/1678-4324-2019180531
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| Formato: |
text/html
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| Fonte: |
Brazilian Archives of Biology and Technology v.62 2019
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| Direitos: |
info:eu-repo/semantics/openAccess
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